MFNG — MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFNG belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MFNG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Leukocyte adhesion signaling migration & adhesion | ARHGDIB, BIN1, CD37, DGKA, DGKZ, EIF3F, EIF3L, EIF4B +22 more | View in SCUBA |
| Gamma-delta T cells | Lymphocyte Homeostatic Regulation Housekeeping | BSG, CTDSP1, FBXW5, HMGN4, IGSF8, IKBKG, LRP10, RASAL3 +8 more | |
| Innate lymphoid cells | ILC1 Actin Motility Cytoskeleton & motility | ACAP1, ARHGDIB, CORO1A, DGCR6L, EVL, GPSM3, HEXA, LCK +14 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Surface Signaling TCR Signaling | CD37, ICAM3, LIME1, MZT2A, NAA10, PLSCR3, SIGIRR |
About the gene
| Chromosome | 22: 37469063-37486393 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Developmental protein, Glycosyltransferase, Transferase |
Function
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (By similarity). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.