RASAL3 — RAS protein activator like 3
RASAL3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RASAL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | ER-Golgi Trafficking Protein processing & ER | ALG5, CNIH4, HDDC3, KDELR1, ORMDL2, PYCARD, RAB8A, RBM42 +4 more | View in SCUBA |
| Gamma-delta T cells | Lymphocyte Homeostatic Regulation Housekeeping | BSG, CTDSP1, FBXW5, HMGN4, IGSF8, IKBKG, LRP10, MFNG +8 more | |
| Innate lymphoid cells | JAK-STAT Cytokine Signaling Inflammation | AASDHPPT, ARHGAP9, CHURC1, CIDEB, CSK, DCAF7, DENND2D, EDEM2 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | TCR Signaling Identity TCR Signaling | ACAP1, CASP4, CD3G, CENPT, CFAP97, DPP7, FBXW5, IL27RA +10 more |
About the gene
| Synonyms | FLJ21438 |
|---|---|
| Chromosome | 19: 15451624-15464544 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | GTPase activation |
Function
Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down- stream ERK signaling pathway
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.