CTDSP1 — CTD small phosphatase 1
CTDSP1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTDSP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th17 effector Th17 fate | CD6, CLSTN3, IL17A, ITPRIPL2, MAP3K4, MPRIP, NFIL3, NMRK1 +6 more | View in SCUBA |
| Gamma-delta T cells | Lymphocyte Homeostatic Regulation Housekeeping | BSG, FBXW5, HMGN4, IGSF8, IKBKG, LRP10, MFNG, RASAL3 +8 more | |
| Innate lymphoid cells | Transcriptional Regulation DNA regulation & transcription | ACAA1, ATRX, C1orf43, CARHSP1, CHTOP, CTR9, DRAP1, ELOVL6 +18 more | View in SCUBA |
| Mucosal-associated invariant T cell | RNA Biogenesis & Folding Housekeeping | ADH5, CCT3, FAM117A, FKBP1A, FKBP8, LSM4, MAT2B, MFSD10 +6 more |
About the gene
| Synonyms | NLIIF, SCP1 |
|---|---|
| Chromosome | 2: 218398256-218405941 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.