Lymphocyte Homeostatic Regulation
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 17 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include CTDSP1 (phosphatase), TSC22D4 (stress-responsive transcription factor), FBXW5 (E3 ubiquitin ligase), RASAL3 (RAS-GAP expressed in T cells), SERPINB1 (protease inhibitor in lymphocytes), IKBKG (NF-κB essential modulator), BSG (CD147, broadly expressed), and MFNG (Notch modifier). The module is uniformly expressed across subsets with moderate mean expression. These genes collectively reflect a broad regulatory/homeostatic program with T cell-relevant signaling (NF-κB via IKBKG, RAS via RASAL3, Notch via MFNG). No single dominant effector pathway. RASSF1 and SHISA5 add apoptosis regulation. This resembles a general lymphocyte homeostatic maintenance program.
Genes
BSG, CTDSP1, FBXW5, HMGN4, IGSF8, IKBKG, LRP10, MFNG, RASAL3, RASSF1, SERPINB1, SHISA5, SLC25A20, SLC27A3, TMED9, TMEM50A, TSC22D4
Most correlated modules
- Effector Cell Migration · correlation 0.93
- ER-Lysosomal Trafficking · correlation 0.90
- NKG2D Cytotoxic Activation · correlation 0.89
- T-bet Effector Differentiation · correlation 0.88
- TCR Vesicular Trafficking · correlation 0.88
- Basal Cell Maintenance · correlation 0.88
- T Cell Homeostasis · correlation 0.87
- Actin Remodeling · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.