ING5 — Inhibitor of growth family member 5
ING5 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ING5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Pre-mRNA Splicing RNA processing & translation | ATXN7L3B, HNRNPDL, NPRL3, PRPF38B, RBFA, RTKN, SREK1, SRSF11 +4 more | View in SCUBA |
About the gene
| Synonyms | FLJ23842, p28ING5 |
|---|---|
| Chromosome | 2: 241687085-241729478 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Activator, Chromatin regulator |
| Biological process | Transcription, Transcription regulation |
Function
Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.