SREK1 — Splicing regulatory glutamic acid and lysine rich protein 1
SREK1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SREK1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chromatin Regulation DNA/chromatin regulation | ADI1, ASXL2, BTG3, CASP8, CHD3, CTSS, CWF19L2, DENND2D +17 more | View in SCUBA |
| Gamma-delta T cells | Spliceosome Regulation RNA processing & translation | AFF1, ATOSA, CEP95, CSNK1A1, FAM13B, KANSL3, KIF5B, MYSM1 +15 more | |
| Innate lymphoid cells | Transcriptional Regulation DNA regulation & transcription | ACAA1, ATRX, C1orf43, CARHSP1, CHTOP, CTDSP1, CTR9, DRAP1 +18 more | View in SCUBA |
| Macrophages | Pre-mRNA Splicing Housekeeping | AAK1, ANKRD12, ANKRD13D, ARGLU1, BRD2, C3orf62, CREBZF, DMTF1 +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin & Splicing DNA/chromatin regulation | ACIN1, ADAR, API5, BAZ2A, CDC73, CDK12, COPA, FUBP1 +11 more | |
| Neutrophils | mRNA Splicing Processing Housekeeping | ABCA13, ATP2A3, EMB, FBXO9, LUC7L3, NKTR, OGT, PAXBP1 +8 more |
About the gene
| Synonyms | DKFZp564B176, SFRS12, SRrp508, SRrp86 |
|---|---|
| Chromosome | 5: 66139971-66183615 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | mRNA processing, mRNA splicing |
Function
Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.