Pre-mRNA Splicing
Gene co-expression module in Colonocytes
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub gene PRPF38B is a spliceosomal B-complex factor; SRSF6, SRSF11, SREK1, and HNRNPDL are all SR/hnRNP splicing regulators. TAF1D is an RNA Pol I transcription factor subunit, TRMT1 is a tRNA methyltransferase, USP36 is a nucleolar deubiquitinase, ING5 is part of the HBO1 histone acetyltransferase complex, ATXN7L3B is a SAGA complex deubiquitinase module component, and NPRL3 is a GATOR1 complex member. The module is core-coherent with slight crypt colonocyte enrichment for RBFA, TRMT1, ING5, and RTKN. The dominant program is pre-mRNA splicing with auxiliary chromatin/transcription components, neighbor to M43 and M90 which share splicing identity.
Genes
Most correlated modules
- SWI-SNF DNA Repair · correlation 0.91
- DNA Repair Housekeeping · correlation 0.90
- Ribosome Biogenesis · correlation 0.89
- Splicing Regulation · correlation 0.88
- Transcription-Coupled Splicing · correlation 0.87
- Chromatin-Coupled Splicing · correlation 0.87
- RNA Splicing Processing · correlation 0.86
- Mitochondrial Biogenesis · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.