KSR2 — Kinase suppressor of ras 2
KSR2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KSR2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Tfh CXCL13 program B cell help | ASCL2, C11orf96, CD8B2, CXCL13, CXXC5, FILIP1L, FZD3, GFOD1 +5 more | View in SCUBA |
About the gene
| Synonyms | FLJ25965 |
|---|---|
| Chromosome | 12: 117453012-117968990 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Function
Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1. Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF- kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.