FILIP1L — Filamin A interacting protein 1 like
FILIP1L belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FILIP1L's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Tfh CXCL13 program B cell help | ASCL2, C11orf96, CD8B2, CXCL13, CXXC5, FZD3, GFOD1, GNG4 +5 more | View in SCUBA |
| Endothelial | Inflammatory Angiogenesis Inflammation | AZIN1, DHH, FBLN5, GJA5, ITSN2, NUDT4, OCIAD2, PIK3C2B +6 more | View in SCUBA |
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | ATP2A2, BAMBI, C5AR2, CRISPLD2, CSNK1E, CTNNB1, DLC1, ETS2 +11 more | View in SCUBA |
| Pericytes | Pericyte Inflammatory Activation Inflammatory | BATF3, CRISPLD2, KCNJ8, MARCKS, PAG1, PDGFA, RHOBTB3, RHOQ +3 more | View in SCUBA |
| Smooth muscle cells | Non-muscle Actomyosin Cytoskeletal | C1R, CAST, CD63, CLIC1, DYNLL1, LDHA, LIMS1, MYH9 +4 more | View in SCUBA |
About the gene
| Synonyms | DOC-1, GIP130 |
|---|---|
| Chromosome | 3: 99828811-100114513 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.