Tfh CXCL13 program
Gene co-expression module in CD4⁺ T cells
| Category | B cell help |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 14 genes have a known function matching the annotation |
Why this annotation
Tfh/Wnt-associated program: CXCL13 (Tfh chemokine), POU2AF1 (OBF-1, B cell help cofactor), ASCL2 (Wnt-induced Tfh fate TF), FZD3 (Wnt receptor), GNG4. ASCL2 and CXCL13 are bona fide Tfh program drivers. CD8B2 is likely noise. Consistent with the surrounding Tfh neighborhood.
Genes
ASCL2, C11orf96, CD8B2, CXCL13, CXXC5, FILIP1L, FZD3, GFOD1, GNG4, ITGB8, KSR2, NTRK3, POU2AF1, PTPN14
Most correlated modules
- Tfh program · correlation 0.72
- NFAT activation · correlation 0.72
- CD200 immunoregulation · correlation 0.72
- Tfh IL21 help · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.