LILRB2 — Leukocyte immunoglobulin like receptor B2
LILRB2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LILRB2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Lymphoid-Primed Progenitor Lymphcyte development | ARHGAP27, CD22, COBLL1, LTB, PACSIN1, S100Z, SH3TC1, SLC2A5 +4 more | |
| Monocytes | Myeloid Innate Receptor Signaling Innate immunity | CYTIP, HCK, JPT1, LILRA5, MYD88, PAG1, PILRA, SERPINA1 | View in SCUBA |
About the gene
| Synonyms | CD85d, ILT4, LIR-2, LIR2, MIR-10, MIR10 |
|---|---|
| Chromosome | 19: 54273812-54281184 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Adaptive immunity, Immunity |
Function
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.