Lymphoid-Primed Progenitor
Gene co-expression module in Hematopoietic progenitor cells
| Category | Lymphcyte development |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
LILRB2 is an inhibitory receptor expressed on myeloid cells and also on lymphoid-primed progenitors. CD22 is a B-cell co-receptor marking B-lineage cells. LTB (lymphotoxin-beta) is a TNF superfamily cytokine expressed by lymphocytes. TRBV28 is a T-cell receptor V-segment gene whose presence in an HPC module at very low pct positive (3.8%) suggests either a rare T-lineage-primed progenitor or low-level contamination. COBLL1 is expressed in monocytes and myeloid-biased progenitors. SLC2A5 (GLUT5/fructose transporter) is enriched in monocytes. TNFAIP2 is TNF-induced and expressed in myeloid/lymphoid activated cells. S100Z is expressed in granulocytes. The very low expression and mixed myeloid/lymphoid signature suggests a lymphoid-primed multipotent progenitor (LMPP) or early lymphoid progenitor state, with possible minor contamination from mature lymphocytes.
Genes
ARHGAP27, CD22, COBLL1, LILRB2, LTB, PACSIN1, S100Z, SH3TC1, SLC2A5, TMEM273, TNFAIP2, TP53I11, TRBV28
Most correlated modules
- HOX HSC Program · correlation 0.91
- Lymphoid Progenitor Commitment · correlation 0.89
- Myeloid Commitment · correlation 0.88
- Multipotent Progenitor Identity · correlation 0.88
- Naive B Cell · correlation 0.86
- Lymphoid Progenitor TFs · correlation 0.81
- Quiescent HSC State · correlation 0.80
- Early Myeloid Progenitor · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.