PACSIN1 — Protein kinase C and casein kinase substrate in neurons 1
PACSIN1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PACSIN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Naïve T Cell State T cell maturation | ARL14EP, CCR2, CD27, CD28, CD40LG, CD82, CNN2, CPNE2 +19 more | |
| Hematopoietic progenitor cells | Lymphoid-Primed Progenitor Lymphcyte development | ARHGAP27, CD22, COBLL1, LILRB2, LTB, S100Z, SH3TC1, SLC2A5 +4 more |
About the gene
| Synonyms | SDPI |
|---|---|
| Chromosome | 6: 34466061-34535229 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Endocytosis |
Function
Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.