LTB — Lymphotoxin beta

LTB belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

LTB's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	B cell activation signaling B cell maturation	ANKRD44, BLK, BTN3A2, EVI2B, GAPT, GPSM3, LBH, LY86 +9 more	View in SCUBA
CD8⁺ T cells	Ribosome Biogenesis RNA processing & translation	BTF3, CCND3, EIF3H, EIF3L, ERP29, FBL, FXYD5, LDHB +8 more	View in SCUBA
Gamma-delta T cells	Naïve T Cell State T cell maturation	ARL14EP, CCR2, CD27, CD28, CD40LG, CD82, CNN2, CPNE2 +19 more
Hematopoietic progenitor cells	Lymphoid-Primed Progenitor Lymphcyte development	ARHGAP27, CD22, COBLL1, LILRB2, PACSIN1, S100Z, SH3TC1, SLC2A5 +4 more
Innate lymphoid cells	ILC-1 identity Differentiation	ABRACL, BLOC1S1, C19orf53, CD52, DAD1, FUCA2, GMFG, HMGN3 +20 more	View in SCUBA
Monocytes	Non-classical Monocyte Migration Migration & adhesion	ADGRE1, CX3CR1, ITGA4, ITGAL, LILRA1, SCLT1, SH2D3C, UTRN	View in SCUBA
Mucosal-associated invariant T cell	Cytotoxic Lymphocyte Program cytotoxicity	ANXA11, CDKN2D, CYB5A, EMP3, ETHE1, FLT3LG, GLIPR2, LDHB +9 more
Natural Killer cells	ILC1-like NK Subset Gut residency	CD2, IL12RB2, IL7R, KLRC1, SELL, SPTSSB, TMEM123, TNFSF10 +2 more	View in SCUBA
Neutrophils	Neutrophil Motility Cytoskeleton Migration & adhesion	CDKN2D, CNN2, COTL1, CST7, GLIPR1, GMFG, GNB2, GPSM3 +9 more

About the gene

Synonyms	p33, TNFC, TNFSF3
Chromosome	6: 31580525-31582522
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Molecular function	Cytokine

Function

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.