LILRB3 — Leukocyte immunoglobulin like receptor B3
LILRB3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LILRB3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Monocyte Innate Signaling Innate immunity | ADAMTSL4, IRAK1, MMP24OS, MYO1G, PGAP6, PLIN3, SHKBP1, STXBP2 +2 more | View in SCUBA |
| Neutrophils | TLR Lipid Signaling Innate immunity | DGAT2, IFNAR1, MBOAT7, NOTCH1, PPP1R3B, STEAP4, TLR1, TLR4 +1 more |
About the gene
| Synonyms | CD85a, HL9, ILT5, LIR-3, LIR3, PIR-B, PIRB |
|---|---|
| Chromosome | 19: 54216278-54223506 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Adaptive immunity, Immunity |
Function
May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine- based inhibitor motifs (ITIM)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.