PLIN3 — Perilipin 3
PLIN3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLIN3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Surface colonocyte lipid-droplet Lipid metabolism | ALPI, CDKN1A, CIDEB, CIDEC, IL32, LMO7, LPGAT1, MPP1 +4 more | View in SCUBA |
| Fibroblasts | Lysosomal Stress Response Stress | ARPC1B, ATP6V0B, CTSB, FAM20C, GSTO1, IKBIP, MIF, PDLIM4 +3 more | View in SCUBA |
| Macrophages | Monocyte Innate Signaling Innate immunity | ADAMTSL4, IRAK1, LILRB3, MMP24OS, MYO1G, PGAP6, SHKBP1, STXBP2 +2 more | View in SCUBA |
About the gene
| Synonyms | M6PRBP1, PP17, TIP47 |
|---|---|
| Chromosome | 19: 4838341-4867694 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Biological process | Transport |
Function
Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.