STXBP2 — Syntaxin binding protein 2
STXBP2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
STXBP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Actin-based Motility Cytoskeletal | APBB1IP, CD58, COMMD7, CORO1B, CTSD, EVL, FDFT1, HMOX2 +13 more | |
| Innate lymphoid cells | ILC1 Cytoskeletal Metabolic Cytoskeleton & motility | ATP5F1B, ATXN10, CCT7, CD82, DNPH1, GADD45GIP1, HMGA1, MEA1 +14 more | View in SCUBA |
| Macrophages | Monocyte Innate Signaling Innate immunity | ADAMTSL4, IRAK1, LILRB3, MMP24OS, MYO1G, PGAP6, PLIN3, SHKBP1 +2 more | View in SCUBA |
About the gene
| Synonyms | Hunc18b, MUNC18-2, Unc18-2, UNC18B |
|---|---|
| Chromosome | 19: 7636772-7647873 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Exocytosis, Protein transport, Transport |
Function
Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.