Monocyte Innate Signaling
Gene co-expression module in Macrophages
| Category | Innate immunity |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Top hub genes include ZNF281 (macrophage differentiation transcription factor), IRAK1 (IL-1R/TLR downstream kinase, central innate immune signaling), LILRB3 (inhibitory leukocyte immunoglobulin-like receptor expressed on myeloid cells), STXBP2 (SNARE-binding protein involved in secretory lysosome exocytosis), VAMP4 (vesicle-associated membrane protein for secretory trafficking), and MYO1G (myosin involved in macrophage phagocytosis and immune synapse). Strong mono_mac enrichment (up to 4.2x). The combination of TLR/IL-1R signaling (IRAK1), inhibitory myeloid receptor (LILRB3), and secretory machinery (STXBP2, VAMP4) suggests a monocyte innate immune regulatory/signaling module balancing activation and inhibition.
Genes
ADAMTSL4, IRAK1, LILRB3, MMP24OS, MYO1G, PGAP6, PLIN3, SHKBP1, STXBP2, VAMP4, ZNF281
Most correlated modules
- Phagocytic Endolysosomal · correlation 0.95
- Autophagy Lysosomal Regulation · correlation 0.93
- Osmotic Stress Response · correlation 0.90
- Inflammatory Monocyte Activation · correlation 0.89
- Inflammatory Monocyte Activation · correlation 0.89
- Hypoxia-driven Activation · correlation 0.88
- RNA Processing Housekeeping · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.