MYO1G — Myosin IG
MYO1G belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MYO1G's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Leukocyte Motility migration & adhesion | ATP2A3, HSH2D, LRP12, LZTFL1, MYO9B, NBEAL2, PPARG, TBC1D31 +1 more | View in SCUBA |
| Gamma-delta T cells | γδ T Cell Identity T cell maturation | AGAP1, AGPAT4, C1orf21, CD226, CD47, GAS7, ITGA5, ITGAM +7 more | |
| Macrophages | Monocyte Innate Signaling Innate immunity | ADAMTSL4, IRAK1, LILRB3, MMP24OS, PGAP6, PLIN3, SHKBP1, STXBP2 +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Remodeling Migration migration & adhesion | ADAM8, BIN2, C11orf21, CAPN1, CAPN2, CD52, CDC25B, CNN2 +14 more | |
| Natural Killer cells | Cytoskeletal Remodeling Cytoskeleton & motility | ADD3, ARHGAP25, ARHGEF3, C1orf21, CAPN2, CYTH1, DGKZ, DIP2A +4 more | View in SCUBA |
About the gene
| Synonyms | HA-2 |
|---|---|
| Chromosome | 7: 44962662-44979088 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Myosin |
| Biological process | Adaptive immunity, Immunity |
Function
Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.