LSS — Lanosterol synthase
LSS belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LSS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | ER Stress & Lipid Metabolism Nutrient processing | ACSF3, AP1G2, ARHGEF10L, ASPSCR1, CCDC12, CCDC57, CDC37, CHD3 +27 more | View in SCUBA |
About the gene
| Synonyms | OSC |
|---|---|
| Chromosome | 21: 46188141-46228824 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Isomerase |
| Biological process | Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis |
Function
Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.