LTA — Lymphotoxin alpha
LTA belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LTA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TNF activation survival Immune regulation | BCL2L1, CD82, CFLAR, CMSS1, EPOP, IL21R, KCNN4, KDM2B +12 more | View in SCUBA |
About the gene
| Synonyms | LT, TNFB, TNFSF1 |
|---|---|
| Chromosome | 6: 31572054-31574324 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted secreted proteins |
| Molecular function | Cytokine |
Function
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.