TNF activation survival
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 21 genes have a known function matching the annotation |
Why this annotation
Mixed activation/survival module with TNF-family cytokine and receptors (LTA, TNFRSF8/CD30), apoptosis regulators (BCL2L1, CFLAR, TNIP2), IL21R, KCNN4 (T-cell activation K+ channel), PTPN7, CD82. Strong inflammation upregulation. Represents an inflammatory activation/survival program in CD4 T cells (LTA, IL21R, TNFRSF8) consistent with chronic effector activation in IBD.
Genes
BCL2L1, CD82, CFLAR, CMSS1, EPOP, IL21R, KCNN4, KDM2B, LTA, LY75, PDGFA, PTP4A3, PTPN7, SAMD12, SMS, STARD7, STX11, TNFRSF8, TNIP2, UBE2Z, VDAC1
Most correlated modules
- Activated Treg · correlation 0.89
- Proteasome translation · correlation 0.83
- Th1 IL12 response · correlation 0.83
- Nucleotide biosynthesis · correlation 0.83
- RNA processing splicing · correlation 0.79
- ER protein processing · correlation 0.76
- Proteasome/translation · correlation 0.75
- mRNA stability regulation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.