CFLAR — CASP8 and FADD like apoptosis regulator

CFLAR belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CFLAR's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Activated B cell B cell maturation	ARHGAP25, ARID3A, DUSP4, ENTPD1, MYO1F, PIK3R5, PLXNC1, PREX1 +6 more	View in SCUBA
CD4⁺ T cells	TNF activation survival Immune regulation	BCL2L1, CD82, CMSS1, EPOP, IL21R, KCNN4, KDM2B, LTA +12 more	View in SCUBA
Endothelial	Vascular EC Identity Endothelial cell development	AMOTL1, ARFGEF3, ATN1, CAMK1D, CASP10, CCNY, F11R, FGD5 +13 more	View in SCUBA
Gamma-delta T cells	Chromatin Remodeling Signaling DNA/chromatin regulation	AKAP13, BPTF, CARNMT1, CCDC6, CLASP1, CLASP2, DOCK10, FBXW7 +23 more
Lymphatic endothelial	Apoptosis Immune Regulation Immune regulation	A4GALT, COX17, GRINA, MPZL1, NINJ1, OPTN, PAWR, RCN1 +2 more	View in SCUBA
Macrophages	NF-κB Activation Inflammatory	BCL3, BLOC1S6, CD83, CHMP1B, CNOT2, CSRNP1, CYLD, DNAJB6 +33 more	View in SCUBA
Monocytes	IRF1 Innate Activation Innate immunity	BAZ1A, FNIP2, IRF1, MARCKS, NABP1, THAP2, TRIM69, ZFYVE16	View in SCUBA
Mucosal-associated invariant T cell	Apoptosis Regulation Immune regulation	ARF4, ARRDC3, CARD8, CREBZF, MAPRE2, NABP1, PCF11, PPP1R10 +1 more
Smooth muscle cells	IFN-gamma/NF-kB Response Inflammation	ATP6V0B, CCDC71L, CHI3L2, EVA1B, GBP1, GBP2, HSPA8, IL32 +11 more	View in SCUBA

About the gene

Synonyms	c-FLIP, CASH, CASP8AP1, Casper, cFLIP, CLARP, FLAME, FLIP, I-FLICE, MRIT
Chromosome	2: 201116154-201176687
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Enzymes, Predicted intracellular proteins
Biological process	Apoptosis, Host-virus interaction

Function

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.