BCL2L1 — BCL2 like 1
BCL2L1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BCL2L1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TNF activation survival Immune regulation | CD82, CFLAR, CMSS1, EPOP, IL21R, KCNN4, KDM2B, LTA +12 more | View in SCUBA |
| Gamma-delta T cells | T cell Survival T cell maturation | ARFRP1, C6orf47, CHD9, DAXX, DEF6, DENND2D, DHPS, ERGIC2 +26 more | |
| Macrophages | Monocyte-Mac Iron Transport Iron metabolism | ARFIP1, CDS2, CLPB, EHD4, GNB4, HAVCR2, IVNS1ABP, MINDY2 +9 more | View in SCUBA |
| Mucosal-associated invariant T cell | Innate Stress Activation Stress | BATF, BRD8, DNAJA3, FAM13A, IL6ST, LRRN3, OXNAD1, PTGER2 +5 more |
About the gene
| Synonyms | Bcl-X, bcl-xL, bcl-xS, BCL2L, BCLX, PPP1R52 |
|---|---|
| Chromosome | 20: 31664452-31723989 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Predicted membrane proteins, RAS pathway related proteins, Transporters |
| Biological process | Apoptosis, Endocytosis |
Function
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. Isoform Bcl-X(S) promotes apoptosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.