METTL8 — Methyltransferase 8, methylcytidine
METTL8 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
METTL8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA stability regulation Immune regulation | APLP2, ARID5B, CARHSP1, GK, GLCCI1, GRAMD4, HIVEP1, MPG +12 more | View in SCUBA |
| CD8⁺ T cells | Gut Residence Trm Gut residence | CD96, FUT8, ITGAE, MYO7A, NAB1, NAP1L4, PAG1, RAB27A +4 more | View in SCUBA |
About the gene
| Synonyms | FLJ13984, TIP |
|---|---|
| Chromosome | 2: 171315746-171434802 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr). N(3)-methylcytidine methylation modification regulates mitochondrial translation efficiency and is required for activity of the respiratory chain. N(3)-methylcytidine methylation of mitochondrial tRNA(Ser)(UCN) requires the formation of N(6)- dimethylallyladenosine(37) (i6A37) by TRIT1 as prerequisite. May also mediate N(3)- methylcytidine modification of mRNAs. The existence of N(3)-methylcytidine modification on mRNAs is however unclear, and additional evidences are required to confirm the role of the N(3)- methylcytidine-specific mRNA methyltransferase activity of METTL8 in vivo.
Human Protein Atlas · Open Targets
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.