Gut Residence Trm
Gene co-expression module in CD8⁺ T cells
| Category | Gut residence |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Top hub gene ITGAE (CD103) is the defining integrin of tissue-resident memory T cells (Trm) in the gut. FUT8 mediates core fucosylation and is expressed in Trm. RBPJ is the canonical Notch transcriptional effector required for Trm differentiation and gut homing. RAB27A controls lytic granule secretion and is expressed in effector/resident T cells. MYO7A is expressed in intestinal epithelial-associated cells and some Trm. CD96 is an inhibitory/activating NK/T receptor. TSPAN5 and TSPAN14 are tetraspanins involved in immune-cell adhesion. NAB1 is a transcriptional repressor downstream of Egr1, relevant to T cell activation. PAG1 and SLA regulate TCR signaling thresholds. The module coherently reflects gut-resident CD8 T cell identity anchored by ITGAE/CD103 and RBPJ, consistent with intraepithelial Trm in colon/CRC.
Genes
CD96, FUT8, ITGAE, METTL8, MYO7A, NAB1, NAP1L4, PAG1, RAB27A, RBPJ, SLA, TSPAN14, TSPAN5
Most correlated modules
- Proliferating CD8 T cell · correlation 0.91
- TCR Activation & Modulation · correlation 0.91
- Cytotoxic Exhausted CD8 · correlation 0.87
- TCR Proximal Signaling · correlation 0.86
- BATF-driven Activation · correlation 0.84
- Tumor mediated exhaustion · correlation 0.83
- Chromatin RNA Processing · correlation 0.82
- IFN-gamma Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.