MMP12 — Matrix metallopeptidase 12
MMP12 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MMP12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, ASPH, BCAT1, BEX3, BHLHE41, BNIP3 +34 more | View in SCUBA |
About the gene
| Synonyms | HME |
|---|---|
| Chromosome | 11: 102862736-102874982 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Predicted secreted proteins |
| Molecular function | Hydrolase, Metalloprotease, Protease |
Function
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.