ASPH — Aspartate beta-hydroxylase
ASPH belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ASPH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Lysosomal Autophagy Program Stress | ABCD4, AKR1A1, CD63, CFI, EBP, GNS, MAP1LC3A, MDH1 +4 more | View in SCUBA |
| Gamma-delta T cells | Effector Cytokine Secretion Inflammation | APBA2, CCL3, CCL4, CMC1, CYRIA, DTHD1, DTNBP1, FCRL3 +25 more | |
| Glial cells | Glial Synaptic Adhesion Neroprotection | AHNAK, ATP1A2, CADM2, GATM, GRIK3, NRXN3, PCDH9, SPTBN1 +1 more | View in SCUBA |
| Goblet cells | Mucin O-Glycosylation Mucus production & secretion | ACLY, C9orf152, CKAP4, ESRP1, FABP2, IL13RA1, PLPP5, RAB2A +8 more | View in SCUBA |
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, BCAT1, BEX3, BHLHE41, BNIP3, CAPN2 +34 more | View in SCUBA |
| Monocytes | IgA-Monocyte Activation Innate immunity | AATK, AREG, ATP2A3, CD82, FCAR, NIBAN2, SERPINB2, SLC16A6 +3 more | View in SCUBA |
About the gene
| Synonyms | BAH, CASQ2BP1, HAAH, JCTN |
|---|---|
| Chromosome | 8: 61500556-61714640 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Dioxygenase, Oxidoreductase |
Function
Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. Membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.