BCAT1 — Branched chain amino acid transaminase 1
BCAT1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BCAT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NFAT activation TCR/AP1/NFKb pathway | AHI1, ASAP1, BICDL1, CPM, CYP7B1, ETV6, FAM107B, FKBP5 +13 more | View in SCUBA |
| Endothelial | Quiescent EC Identity Endothelial cell development | ADGRG6, C3orf80, CELF2, CPE, KLF8, KLK10, LYST, PCDH19 +5 more | View in SCUBA |
| Lymphatic endothelial | Hippo-mTOR Quiescence endothelial development | FILIP1, FRMD6, KLHL3, LAMA4, NIBAN1, PRR5L, SCN9A | View in SCUBA |
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, ASPH, BEX3, BHLHE41, BNIP3, CAPN2 +34 more | View in SCUBA |
| Monocytes | Tissue-destructive Macrophage Lysosomal & pahgocytosis | ACP5, ANKH, ENG, FABP5, ID3, IL10, KIFC3, LDLRAD4 +7 more | View in SCUBA |
About the gene
| Synonyms | BCATc, BCT1 |
|---|---|
| Chromosome | 12: 24810024-24949101 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Aminotransferase, Transferase |
| Biological process | Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Lipid metabolism |
Function
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.