BEX3 — Brain expressed X-linked 3
BEX3 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BEX3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | LAYN+ tissue Treg Immune regulation | CADM1, CHRNA6, EPHX2, FLVCR2, GNG8, IKZF4, LAPTM4B, LAYN +7 more | View in SCUBA |
| Glial cells | Glial Vesicle Trafficking Housekeeping | CCNI, FKBP1A, HMGN2, ITM2C, PGRMC1, PLD3, TCEAL7, TUBB +1 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic EC Identity endothelial development | ATP6AP2, CD151, FDPS, GNG11, LMO2, MGST3, NAA38, POLR2L +2 more | View in SCUBA |
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, ASPH, BCAT1, BHLHE41, BNIP3, CAPN2 +34 more | View in SCUBA |
| Smooth muscle cells | mRNA Splicing Factors RNA processing & translation | ATF4, CLIC4, COX20, HNRNPA0, NAP1L1, NDUFA6, NME4, PCBP1 +7 more | View in SCUBA |
About the gene
| Synonyms | Bex, DXS6984E, HGR74, NADE, NGFRAP1 |
|---|---|
| Chromosome | X: 103376395-103378164 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Apoptosis |
Function
May be a signaling adapter molecule involved in NGFR/p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.