MTHFR — Methylenetetrahydrofolate reductase
MTHFR belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MTHFR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Senescent Colonocyte Transcription Senescence & shedding | ABCC5, CFDP1, DAZAP2, GABARAPL1, GRAMD2B, HNF4A, INSR, IST1 +8 more | View in SCUBA |
About the gene
| Chromosome | 1: 11785723-11806455 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Allosteric enzyme, Oxidoreductase |
Function
Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Represents a key regulatory connection between the folate and methionine cycles (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.