NAE1 — NEDD8 activating enzyme E1 subunit 1
NAE1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NAE1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | BEST4+ Colonocyte Identity Epithelial development | ABI3BP, ADAMTS14, ADCY5, ANO7, ATOH8, BEST4, BMP2K, CA7 +33 more | View in SCUBA |
About the gene
| Synonyms | APP-BP1, APPBP1, ula-1 |
|---|---|
| Chromosome | 16: 66802875-66873256 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Biological process | Apoptosis, Cell cycle, Ubl conjugation pathway |
Function
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.