NOG — Noggin
NOG belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NOG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T cell T cell development | AIF1, AK5, APBA2, BEND5, BEX2, C1orf162, CBR3, CYSLTR1 +21 more | View in SCUBA |
| Hematopoietic progenitor cells | Cytokine Feedback Signaling Inflammatory | ANKRD28, ATP8B4, BEX1, CALCOCO2, RHEX, SELL, SOCS3, SYT1 +2 more |
About the gene
| Synonyms | SYM1, SYNS1 |
|---|---|
| Chromosome | 17: 56593699-56595611 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Chondrogenesis, Differentiation |
Function
Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.