Cytokine Feedback Signaling
Gene co-expression module in Hematopoietic progenitor cells
| Category | Inflammatory |
|---|---|
| Genes | 11 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
SOCS3 is a feedback inhibitor of JAK-STAT cytokine signaling, induced downstream of multiple cytokines. NOG (Noggin) is a BMP pathway antagonist involved in niche signaling. SELL (L-selectin/CD62L) mediates progenitor and lymphocyte homing. RHEX is specifically expressed in erythroid progenitors and regulates differentiation. CALCOCO2 mediates selective autophagy linked to innate immune responses. BEX1 and TLE4 are transcriptional regulators in progenitors. The module represents a cytokine/niche-responsive progenitor signaling state dominated by SOCS3-mediated cytokine feedback.
Genes
ANKRD28, ATP8B4, BEX1, CALCOCO2, NOG, RHEX, SELL, SOCS3, SYT1, TLE4, WDR49
Most correlated modules
- HSC Stem Identity · correlation 0.71
- Cytoskeletal Remodeling · correlation 0.67
- T-cell Progenitor · correlation 0.64
- Metabolic Housekeeping · correlation 0.61
- Granulocyte Commitment · correlation 0.56
- Interferon Stimulated · correlation 0.54
- Erythroid Glycolysis · correlation 0.45
- Multipotent Progenitor State · correlation 0.42
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.