SYT1 — Synaptotagmin 1

SYT1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SYT1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	BCR Ras signaling BCR/AP1/NFKb pathway	ANKRD28, CCL5, DOK3, GSTK1, GYPC, HOPX, HSH2D, ITGAM +12 more	View in SCUBA
Endothelial	YAP Mechanotransduction migration & adhesion	COBLL1, CREB5, DEPP1, DST, FGL2, FLNC, FN1, GCNT2 +7 more	View in SCUBA
Fibroblasts	OSR1+ Deep Fibroblast Developmental	EMCN, EPHA3, HS3ST6, ID4, OMG, OSR1, PCLO, PPP1R1B +5 more	View in SCUBA
Hematopoietic progenitor cells	Cytokine Feedback Signaling Inflammatory	ANKRD28, ATP8B4, BEX1, CALCOCO2, NOG, RHEX, SELL, SOCS3 +2 more

About the gene

Synonyms	P65, SVP65, SYT
Chromosome	12: 78863993-79452008
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Biological process	Differentiation

Function

Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.