NOL8 — Nucleolar protein 8
NOL8 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NOL8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Immune Negative Regulation Immune regulation | ATAD1, CABIN1, DGLUCY, FYB1, GMIP, ICE2, KMT5B, NFX1 +4 more |
About the gene
| Synonyms | C9orf34, FLJ20736, Nop132 |
|---|---|
| Chromosome | 9: 92297358-92325636 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | rRNA processing |
Function
Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post- transcriptional level or in ribosome biogenesis in cancer cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.