NPR3 — Natriuretic peptide receptor 3
NPR3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NPR3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | HSC Stem Identity Stemness | ANGPT1, APLP2, CALN1, ERG, LYSMD2, MSRB3, SERPINB6, TFEC |
About the gene
| Synonyms | ANPRC, C5orf23, FLJ14054, GUCY2B, NPRC |
|---|---|
| Chromosome | 5: 32689070-32791724 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.