TFEC — Transcription factor EC
TFEC belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TFEC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell activation B cell maturation | CCDC50, IL10RA, NCR3, PTPN12, RBM47, RORA, SAMSN1, TBC1D9 +4 more | View in SCUBA |
| Enterocytes | Xenobiotic Detoxification Nutrient metabolism | ARHGDIG, FAM151A, FMO1, GSTA2, HADH, HSD3B1, IDH1, KCNJ13 +1 more | View in SCUBA |
| Hematopoietic progenitor cells | HSC Stem Identity Stemness | ANGPT1, APLP2, CALN1, ERG, LYSMD2, MSRB3, NPR3, SERPINB6 | |
| Macrophages | Antiviral ISG Response Antiviral | ADAR, APOL6, ARID5A, CLEC7A, DDX60, DTX3L, EIF2AK2, ERICH1 +29 more | View in SCUBA |
About the gene
| Synonyms | bHLHe34, TCFEC, TFECL |
|---|---|
| Chromosome | 7: 115935148-116159896 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.