NUGGC — Nuclear GTPase, germinal center associated
NUGGC belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NUGGC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin Repression DNA/chromatin regulation | CAPN12, CFAP210, CNOT10, EPS8L2, FKBP5, H1-10, HAGHL, IL6ST +8 more |
About the gene
| Synonyms | C8orf80, HMFN0672, SLIP-GC |
|---|---|
| Chromosome | 8: 28021964-28083936 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA. Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.