Chromatin Repression
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include IL6ST (gp130, IL-6 family cytokine co-receptor for T cell survival/differentiation), SCML4 (Polycomb chromatin repressor), SAP30 (Sin3A HDAC complex, transcriptional repression), H1-10 (histone H1 variant, chromatin compaction), METTL24 (methyltransferase), CNOT10 (CCR4-NOT mRNA deadenylation/RNA regulation), TLE1 (transcriptional co-repressor), FKBP5 (glucocorticoid/stress response), and SESN1 (p53 target, stress/mTOR). The convergence of chromatin repressors (SAP30, SCML4, H1-10, TLE1) with stress sensors (SESN1, FKBP5) and cytokine receptor IL6ST suggests a quiescent or stress-responsive transcriptional repression state. As a topological neighbor of M27 (immature T cell program), this likely reflects epigenetic silencing programs associated with T cell development or quiescence.
Genes
CAPN12, CFAP210, CNOT10, EPS8L2, FKBP5, H1-10, HAGHL, IL6ST, METTL24, MPZL3, NUGGC, SAP30, SCML4, SESN1, SNTB2, TLE1, TMEM156
Most correlated modules
- Tissue Resident CD103+ · correlation 0.91
- NK Receptor Expression · correlation 0.90
- mRNA Splicing Regulation · correlation 0.84
- Hypoxia Tissue Adaptation · correlation 0.80
- Gut-homing Residence · correlation 0.80
- Activation Stress Response · correlation 0.80
- Chromatin Remodeling Signaling · correlation 0.78
- Pre-mRNA Splicing · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.