H1-10 — H1.10 linker histone
H1-10 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
H1-10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin Repression DNA/chromatin regulation | CAPN12, CFAP210, CNOT10, EPS8L2, FKBP5, HAGHL, IL6ST, METTL24 +8 more | |
| Innate lymphoid cells | ILC3 identity Differentiation | ABCC1, BCL6, CCND3, CELF2, CHKB, DNAAF2, ENSG00000285976, EREG +31 more | View in SCUBA |
| Monocytes | Histone Chromatin Remodeling Housekeeping | CTSD, H1-2, H1-3, H1-4, H2AJ, H4C3, HMGB2, HOXA9 | View in SCUBA |
| Mucosal-associated invariant T cell | MAIT Cell Identity T cell maturation | AFF3, DDX3Y, DKK3, DSE, EPAS1, FKBP5, FYN, GLIPR1 +16 more | |
| Natural Killer cells | Replication-Coupled Histones Cell cycle | H1-2, H1-3, H1-4, H2AC6, H2AC8, H2BC15, H2BC4, H4C3 | View in SCUBA |
About the gene
| Synonyms | H1FX, H1X, MGC15959, MGC8350 |
|---|---|
| Chromosome | 3: 129314771-129316286 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
Function
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.