NUP214 — Nucleoporin 214
NUP214 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NUP214's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NK/T Cell Identity T cell maturation | AFTPH, ARHGAP17, ASXL2, ATF7IP, CALCOCO2, CD244, CLK3, GDI1 +24 more |
About the gene
| Synonyms | CAIN, CAN, D9S46E, N214 |
|---|---|
| Chromosome | 9: 131125573-131234663 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Biological process | Host-virus interaction, mRNA transport, Protein transport, Translocation, Transport |
Function
Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.