GDI1 — GDP dissociation inhibitor 1
GDI1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GDI1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NK/T Cell Identity T cell maturation | AFTPH, ARHGAP17, ASXL2, ATF7IP, CALCOCO2, CD244, CLK3, GPR174 +24 more | |
| Innate lymphoid cells | Interferon-Stimulated Genes Inflammation | ALDOA, CRTAP, DAZAP2, DDX39B, EIF4B, GNB2, GRINA, GSTM2 +17 more | View in SCUBA |
| Mucosal-associated invariant T cell | mRNA Processing Translation RNA processing & translation | ACTN4, CDC42SE1, CSDE1, DDX5, EIF4G1, HNRNPU, MSN, NCL +7 more |
About the gene
| Synonyms | FLJ41411, GDIL, MRX41, MRX48, OPHN2, RABGDIA, XAP-4 |
|---|---|
| Chromosome | X: 154436913-154443467 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.