AFTPH — Aftiphilin
AFTPH belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AFTPH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Immune Regulation Immune regulation | ADAT2, C2CD4B, CDKL2, CPEB4, DDHD1, FAM53B, FAS, FNDC3B +10 more | View in SCUBA |
| Gamma-delta T cells | NK/T Cell Identity T cell maturation | ARHGAP17, ASXL2, ATF7IP, CALCOCO2, CD244, CLK3, GDI1, GPR174 +24 more | |
| Macrophages | ER-Golgi Trafficking Vesicular traficking | ADD1, AZIN1, COPA, DYNC1H1, HNRNPC, JOSD1, LCP2, LRRFIP1 +23 more | View in SCUBA |
About the gene
| Synonyms | FLJ20080, FLJ23793, MGC33965, Nbla10388 |
|---|---|
| Chromosome | 2: 64524299-64593005 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Protein transport, Transport |
Function
Component of clathrin-coated vesicles. Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.