NK/T Cell Identity
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 33 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 33 genes have a known function matching the annotation |
Why this annotation
Hub genes include TAGAP (RhoGEF specifically expressed in T cells downstream of TCR), GPR174 (lymphocyte-expressed GPCR regulating T cell migration), IL2RB (IL-2/IL-15 receptor beta chain, canonical T/NK cell marker), CD244 (2B4/SLAMF4, NK and T cell co-receptor), LY9 (SLAM family lymphocyte antigen 9), PARP14 (ADP-ribosyltransferase in cytokine signaling), and NF1 (RasGAP regulating T cell activation). CALCOCO2 (selective autophagy receptor), ASXL2 (Polycomb chromatin regulator), ATF7IP (chromatin/heterochromatin), and SMG1 (nonsense-mediated decay kinase) fill out immune regulatory functions. This module captures a T/NK cell identity and immune activation regulatory program in gd_T cells, consistent with lymphocyte-specific surface receptors and downstream signaling regulators.
Genes
AFTPH, ARHGAP17, ASXL2, ATF7IP, CALCOCO2, CD244, CLK3, GDI1, GPR174, IL2RB, KIAA1191, KIAA1671, LY9, MARCHF5, NF1, NPEPPS, NUP214, PARP14, PDXDC1, RCOR3, SACM1L, SMG1, STOM, TAGAP, TMEM33, TMEM50B, TOB2, TRIAP1, TRPM7, USP47, YWHAG, ZFP36L1, ZNF217
Most correlated modules
- Metabolic-Translational Coupling · correlation 0.83
- Mitochondrial RNA Processing · correlation 0.82
- Post-transcriptional RNA Regulation · correlation 0.78
- Hippo Pathway Signaling · correlation 0.77
- Chromatin Epigenetic Regulation · correlation 0.77
- Spliceosome Regulation · correlation 0.77
- Centrosome Organization · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.