ATF7IP — Activating transcription factor 7 interacting protein
ATF7IP belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATF7IP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell signaling regulators BCR/AP1/NFKb pathway | AKNA, DNAJB14, FCHSD2, GOLGA4, IKZF3, INPP5D, MYCBP2, PDE7A +3 more | View in SCUBA |
| CD4⁺ T cells | Integrin Adhesion Migration migration & adhesion | ARAP2, C4orf3, CLEC2B, COTL1, CTSH, DEK, DIAPH1, EML4 +11 more | View in SCUBA |
| Gamma-delta T cells | NK/T Cell Identity T cell maturation | AFTPH, ARHGAP17, ASXL2, CALCOCO2, CD244, CLK3, GDI1, GPR174 +24 more | |
| Macrophages | Post-transcriptional Regulation Housekeeping | AKAP10, ATRN, ATXN2, BAZ2B, BLTP1, BRWD1, CELF2, CEP350 +34 more | View in SCUBA |
| Mucosal-associated invariant T cell | STAT4 T cell Identity T cell maturation | CAMK4, CBLB, CD96, CELF2, DENND4A, IKZF1, JMJD1C, PIP4K2A +7 more | |
| Neutrophils | Apoptotic Neutrophil Program Developmental | ANO10, APAF1, ARFGEF1, BLTP1, CEP350, FAR2, FBXW2, HIPK2 +5 more |
About the gene
| Synonyms | ATF7IP1, FLJ10688, p621 |
|---|---|
| Chromosome | 12: 14365676-14502931 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Activator, Repressor |
| Biological process | Host-virus interaction, Transcription, Transcription regulation |
Function
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.