PDHB — Pyruvate dehydrogenase E1 subunit beta
PDHB belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDHB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Oxidative Phosphorylation Mitochondrial & OxPhos | ATP5F1A, ATP5F1C, ATP5MC3, ATP5MG, ATP5PB, ATP5PO, CHCHD3, COA3 +21 more | View in SCUBA |
About the gene
| Synonyms | E1beta, PDHE1B |
|---|---|
| Chromosome | 3: 58427630-58433857 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Carbohydrate metabolism, Glucose metabolism, Tricarboxylic acid cycle |
Function
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.