PHLDA3 — Pleckstrin homology like domain family A member 3
PHLDA3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHLDA3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | p53 DNA-damage response Stress | AEN, APOBEC3H, BBC3, DDB2, FDXR, GZMH, PKIG, RCAN2 | View in SCUBA |
| Fibroblasts | Wnt-Niche Fibroblast Developmental | AHNAK, AHNAK2, AKAP12, CELF2, CYSLTR1, DPYSL3, DST, GAS6 +10 more | View in SCUBA |
About the gene
| Synonyms | TIH1 |
|---|---|
| Chromosome | 1: 201464278-201469237 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Apoptosis |
Function
p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.