GAS6 — Growth arrest specific 6
GAS6 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GAS6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Arterial EC Homeostasis Endothelial cell development | APOL3, BMX, EXOC6, FAXDC2, FTH1, GABARAPL1, GIMAP1, GIMAP4 +10 more | View in SCUBA |
| Fibroblasts | Wnt-Niche Fibroblast Developmental | AHNAK, AHNAK2, AKAP12, CELF2, CYSLTR1, DPYSL3, DST, HSPG2 +10 more | View in SCUBA |
| Goblet cells | Mature Colonocyte Function Epithelial development | ADD3, CERS6, CFTR, LEFTY1, MAOA, NOX1, PDCD4, PLBD1 +2 more | View in SCUBA |
| Macrophages | Resident Mac Identity Tissue homeostasis | ACVRL1, CCND1, CD200R1, CFD, CR1, CTSF, EMB, EPHX1 +16 more | View in SCUBA |
| Monocytes | IFN-gamma Monocyte Activation Inflammatory | BLVRA, CYB5A, DRAP1, FCGR1A, HLA-F, IFITM3, LGALS9, LILRB1 +3 more | View in SCUBA |
| Smooth muscle cells | Synthetic Matrix Phenotype ECM remodeling | APOE, CFD, GJA1, MAP1LC3A, MXRA5, PHF14, PLAU, POSTN +1 more | View in SCUBA |
About the gene
| Synonyms | AXLLG, AXSF, DKFZp666G247, FLJ34709 |
|---|---|
| Chromosome | 13: 113820549-113864076 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Biological process | Growth regulation, Host-virus interaction |
Function
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry. Plays a role in Dengue cell entry by apoptotic mimicry. Plays a role in Vaccinia virus cell entry by apoptotic mimicry. Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.