Wnt-Niche Fibroblast
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes PCDH7 (protocadherin cell adhesion), WNT2B (Wnt ligand marking specific intestinal fibroblast subsets), NTN1 (netrin guidance cue), HSPG2 (perlecan, basement membrane proteoglycan), SEMA3D (semaphorin axon/cell guidance), GAS6 (TAM receptor ligand), and MAF (transcription factor) collectively define a fibroblast niche-organizing program involving Wnt signaling, guidance cues, and cell-cell communication. WNT2B specifically marks a deep submucosal fibroblast population in the intestine. Neighbor context supports a homeostatic stromal identity theme.
Genes
AHNAK, AHNAK2, AKAP12, CELF2, CYSLTR1, DPYSL3, DST, GAS6, HSPG2, KCNJ3, MAF, MMP23B, NTN1, PCDH7, PHLDA3, SEMA3D, TMEM47, TOX3, WNT2B
Most correlated modules
- ECM Homeostasis · correlation 0.79
- Elastin-Fibronectin ECM · correlation 0.73
- TGF-beta Fibroblast Niche · correlation 0.72
- Pericyte-like Fibroblast · correlation 0.71
- Notch Fibroblast Activation · correlation 0.70
- Microfibril ECM Fibroblast · correlation 0.69
- Smooth Muscle Differentiation · correlation 0.67
- Homeostatic Fibroblast Identity · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.